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B12 Homeostasis in action

B12.1 Controlling body temperature (single science only)

Question Answer
What is the normal body temperature? 37 degrees centigrade
Why must the human body be kept around 37 degrees? because this is the temperature at which work best
Which organ can cope with widely varying temperature? the skin
What part of the body needs to be kept at a very stable temperature? the core i.e. deep inside the body
How flexible is body about temperature? it can cope with a few degrees fluctuation either side for short periods of time, but no more, so for example, a body temperature of only 39 degrees is dangerous to life
What can affect the internal body temperature? • heat from muscles during exercise
• fever caused by disease
• large swings in external temperature
What can a person do to regulate their temperature? • turn on heating
• a change of clothing
• go for a swim
• build a fire
What controls the body temperature? the thermoregulatory centre in the hypothalamus in the brain
How does the thermoregulatory centre measure the inner core temperature? it contains receptors that are sensitive to the temperature of the blood
How is the skin in maintaining a stable body temperature? receptors in the skin send information to the thermoregulatory centre
How sensitive are temperature receptors in the skin? they are extremely sensitive able to detect a temperature difference as small as 0.5 °rees; C
What does the body try to do when the core body temperature begins to rise? to transfer energy from the body to the surroundings to bring the body temperature down
Name the two main techniques for reducing body temperature. • vasodilation
• sweating
What is vasodilation? the blood vessels that supply blood to the skin capillaries dilate
What is the effect of vasodilation? • more blood flows close to the skin
energy is transferred by radiation from the skin to the surroundings
the body cools down
Where does sweat come from? from the sweat glands in the skin
Why is the effect of sweating? the water in the sweat evaporates, transferring energy to the environment, and cooling the body
When would sweating not work? in humid weather, the water does not evaporate, making it harder to transfer energy from the body
What is sweat made of? it is mainly water with small amounts of urea, sugar, and mineral ions
Why is it important to drink water in hot weather? to replace the water lost through sweating
Why is it important to drink water when exercising? to replace the water lost through sweating
Why is it not enough to only drink water when sweating? because the body also loses important ions which need to be replaced
How can the mineral ions that are lost through sweating, be replaced? by eating food or drinking juices that contain the ions
What is the effect on cells of the body getting very cold? • the rate of enzyme-controlled reactions in the cells falls
• the cells do not do sufficient respiration to support their activities
• the cells begin to die
What happens when the core body temperature starts to fall? • receptors in the core send impulses to the thermoregulatory centre
• the thermoregulatory centre initiates action to reduce heat loss and/or generate body heat
What can the body do to raise the temperature of the body? • vasoconstriction
• reduced sweating
• shivering
Explain vasoconstriction. • the blood vessels that supply the capillaries in the skin contract
• less blood reaches the surface of the skin
• less heat is radiated to the environment
How does reduced sweating help combat a falling core temperature? less sweating means less water evaporating and hence less energy transferred to the environment
What is shivering? the skeletal muscles contract and relax repeatedly and very quickly
How does shivering help combat falling core body temperature? • muscle contractions increase respiration
• respiration is an exothermic reaction
• the energy released by the exothermic reaction increases body temperature

B12 Homeostasis in action

B12.2 Removing waste products (single science only)

Question Answer
How much urine does a person produce each year? up to 900 litres
What is the main requirement of cells regards conditions? conditions must be kept as constant as possible
List examples of things that change conditions in the body? • exercise increases respiration heating the body
• respiration produces waste products contaminating the blood
• distributing digested food to the cells increases concentrations of substances like amino acids and glucose
Name the process that keeps internal conditions constant in the body. homeostasis
List activities included in homeostasis. • removing waste products
• maintaining water balance
• maintaining mineral levels
• keeping levels of glucose constant
When are waste products produced by the body? they are produced constantly, even during sleep
Where do these waste products come from? they are produced by the chemical reactions in the cells of the body
Name the two main poisonous waste products produced by the body. • urea
• carbon dioxide
What is the effect of waste products on the body? they can cause major problems from damaging organs to death
What is the waste product from respiration? carbon dioxide
Why must the waste product carbon dioxide be removed? because the dissolved carbon dioxide makes the solution acidic which affects the working of the enzymes in the cell
Describe the journey of carbon dioxide in the body. • respiration produces carbon dioxide in the cell
• carbon dioxide diffuses out the cell down a concentration gradient into the blood
• carbon dioxide diffuses out the blood down a concentration gradient into the alveolus
• carbon dioxide is expelled from the body by exhalation
What is the unwanted side effect of exhaling carbon dioxide? the air in the lungs is moist so water is lost by the body
What is urea? the nitrogenous bi-product when excess amino acids are converted to carbohydrates in the liver
Describe the journey of urea. • urea is a bi-product when excess amino acids are broken down in the liver
• urea diffuses from the cells of the liver into the blood
• urea is filtered out the blood by the kidney
• urine (water, urea and slats) moves from the bladder
• urine is expelled from the body by the bladder
What is the effect of urea in the body? it will cause extensive damage to cells and ultimately death if the situation is not resolved
What is the unwanted side effect of urinating? the body loses water and important minerals which can cause problems if not replaced
Where does excess protein come from in the body? • eating too much protein
• breaking down worn out tissues
What does the body do with excess protein? it converts the protein to carbohydrates that the body can use for fuel
Why does the body need to convert excess protein to carbohydrates • excess protein and amino acids cannot be stored in the body
• excess protein cannot be used directly as fuel
Where are proteins and amino acids converted to carbohydrates? in the liver
What is the process of converting proteins and amino acids to carbohydrates called? deamination
What is actually done to convert amino acids to protein? the amino group is removed from the amino acid
What is the byproduct of removing an amino group from amino acids? ammonia NH3
What happens to the ammonia produced by deamination? it is immediately converted to urea
Why is the ammonia of deamination immediately converted to urea? ammonia is highly toxic, and while urea is toxic, it can be removed by the body safely
Why must water levels be kept constant in the body? if the cells of the body lose or gain too much water by osmosis, they cannot function effectively and efficiently
In what ways does the body lose water where it has no control? • water is lost every time a person exhales
• water, mineral ions, and urea are lost through the skin when sweating
How does the body control the levels of water and mineral ions in the body? the kidneys remove urea, excess water, and excess mineral ions which are then excreted in the urine,
What are the main tasks of the kidneys? • to remove urea from the blood
• to maintain water and mineral ion content of the blood within narrow limits

B12 Homeostasis in action

B12.3 The human kidney (single science only)

Question Answer
How many kidneys does a person have? 2
What do the kidneys do? the kidneys remove
• urea
• excess water
• excess mineral ions
Where is urine produced? in the kidneys
How often is urine produced? it is produced constantly
What happens to urine once it has been produced? it is stored in the bladder before being expelled
When does a person gain water? • from drinking
• from eating
When does a person lose water? • sweating
• breathing
• urinating
What is the role of the kidneys in the homeostasis of water? • if short of water, kidneys conserve it and urine is very concentrated
• if there is too much water, kidneys expel it and urine is very dilute
How does the body lose mineral ions? • sweating
• urinating
How does the body get rid of excess mineral ions? the kidneys remove excess mineral attempts and excrete them in the urine
Where are the kidneys? below the liver and the diaphragm and above the bladder
What are the renal arteries? the blood vessels that bring blood to the kidneys
What are the renal veins? the blood vessels that carry blood away from the kidneys
What happens to the blood first when it enters the kidneys? glucose, mineral ions, urea, and water all move out of the blood into the kidney
What part of the blood does not enter the kidneys and why? • the blood cells and proteins do not leave the blood
• because they are too large
How long does it take all the blood in your body to pass through the kidneys? once every 5 minutes
How much water do the kidneys filter out the blood every day on average? 180 litres
On average, how much of the water filtered out the blood is returned to the body? around 99% of it
How much urine is produced each day on average? 1800 cm3
What happens to the urine removed by the kidneys? • it trickles into the bladder where it is stored
• when the bladder is full, it is emptied
What is reabsorped back into the blood? • all the glucose
• all or some of the mineral ions depending on what is needed
• all or some of the water depending on what is needed
What is selective reabsorption? the amount of water and mineral ions reabsorped into the blood varies according to what the body needs
Where does selective reabsorption take place? along the millions of tiny tubules that make up the kidney
How is the water level in blood maintained at a constant level? by a negative feedback loop the uses the hormone ADH
Where does ADH come from? it is secreted by the pituitary gland in the brain
How are changes in concentration levels of solutes in the blood monitored? detectors in the brain monitor the concentration of solutes in the blood plasma
What happens when the blood becomes too concentrated? • detectors in the brain detect an increased concentration of solutes in the blood plasma
• the pituitary gland increases the amount of ADH it releases into the blood
• the increased ADH makes the kidney tubules reabsorp more water
• this reduces the amount of water in the urine
• less urine is produced
• the urine is more concentrated
What happens when the blood becomes too dilute? • detectors in the brain detect a decreased concentration of solutes in the blood plasma
• the pituitary gland reduces the amount of ADH it releases into the blood
• the reduced ADH makes the kidney tubules reabsorp less water
• this increases the amount of water in the urine
• more urine is produced
• the urine is very dilute
Give an example of when urine will be concentrated and relatively dark yellow. a hot day, exercising a lot and drinking very litte
Give an example of when urine will be dilute and almost colourless. a cool day, doing very little and drinking lots of liquids

B12 Homeostasis in action

B12.4 Dialysis - an artifical kidney (single science only)

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B12 Homeostasis in action

B12.5 Kidney transplants (single science only)

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B6 Preventing and treating disease

B6.6 Uses of monoclonal antibodies

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